| ncRNA name | p38 siRNA |
| ncRNA Category | siRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | human Rb cell lines: Y79 and WERI-RB1 |
| Methods | DNA fragmentation assay, [3H]Thymidine incorporation assay, DNA flurometric assay, FACS analysis, transfection, immunoblot, immunoprecipitation |
| Expression pattern | associated |
| Functional description | 2ME induces apoptosis in human Rb cells by causing phosphorylation of p38 Mitogen-activated protein kinase (MAPK), which appears to be correlated with phosphorlation of Bax. Both p38 specific inhibitor, SB 203580, or p38 knockdown by specific siRNA, blocked 2ME induction of Bax phosphorylation. |
| PubMed ID | 21769948 |
| Year | 2012 |
| Title | 2-Methoxyestradiol induced Bax phosphorylation and apoptosis in human retinoblastoma cells via p38 MAPK activation. |
| Drug-related ncRNA | YES (2-Methoxyestradiol (2ME)) |
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